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目的 基于红外热成像技术探讨“扶正温阳法”对阳虚质的影响,探讨阳虚质者红外热图的共性规律,分析判断“扶正温阳法”干预阳虚质人群的疗效。方法 纳入30例阳虚质患者给予益气温阳药物在大椎、肾俞(双侧)、命门等进行穴位贴敷,分别在干预前后运用红外热成像技术测定督脉、腰部、腹部、双手及双足局部温度的变化。结果 干预后阳虚体质患者的督脉、腰部、腹部、双手、双足温度均升高(P<0.05),阳虚体质局部温度得以改善。结论 本研究发现“扶正温阳法”可诱发循经热传导现象,通过调节热能代谢而起到调治阳虚体质的作用,红外热成像技术可用来辅助评价阳虚质的治疗效果,对临床指导制定阳虚质人群的干预方案疗效判定具有指导意义。 相似文献
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PurposeTo evaluate in vivo parameters as biomarkers of limbal stem cell function and to establish an objective system that detects and stage limbal stem cell deficiency (LSCD).MethodsA total of 126 patients (172 eyes) with LSCD and 67 normal subjects (99 eyes) were included in this observational cross-sectional comparative study. Slit-lamp biomicroscopy, in vivo laser scanning confocal microscopy (IVCM), and anterior segment optical coherence tomography (AS-OCT) were performed to obtain the following: clinical score, cell morphology score, basal cell density (BCD), central corneal epithelial thickness (CET), limbal epithelial thickness (LET), total corneal nerve fiber length (CNFL), corneal nerve fiber density (CNFD), corneal nerve branch density (CNBD), and tortuosity coefficient. Their potential correlations with the severity of LSCD were investigated, and cutoff values were determined.ResultsAn increase clinical score correlated with a decrease in central cornea BCD, limbal BCD, CET, mean LET, maximum LET, CNFL, CNFD, CNBD, and tortuosity coefficient. Regression analyses showed that central cornea BCD, CET and CNFL were the best parameters to differentiate LSCD from normal eyes (Coef = 3.123, 3.379, and 2.223; all p < 0.05). The rank correlation analysis showed a similar outcome between the clinical scores and the central cornea BCD (ρ = 0.79), CET (ρ = 0.82), and CNFL (ρ = 0.71). A comprehensive LSCD grading formula based on a combination of these parameters was established.ConclusionsA comprehensive staging system combining clinical presentation, central cornea BCD, CET, and CNFL is established to accurately and objectively diagnose LSCD and stage its severity. 相似文献
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目的 系统评价益气活血法联合西药治疗特发性肺纤维化(idiopathic pulmonary fibrosis,IPF)的疗效及安全性。方法 系统检索中国知网、维普网、万方数据库、EMbase、PubMed、Cochrane Library图书馆等数据库,检索时限从数据库建库至2021年1月,纳入益气活血法联合西药治疗特发性肺纤维化的随机对照试验(randomized controlled trial,RCT),由2名研究人员独立筛选并交叉核对纳入结果,提取有效数据后,应用RevMan 5.3软件进行Meta分析。结果 纳入16项随机对照试验共计1160例IPF患者。分析结果显示益气活血法联合西药组可提高临床总有效率(OR= 3.71,95% CI [2.68,5.14],P<0.00001);改善患者肺功能:用力肺活量(MD=0.31,95% CI [0.23,0.38],P<0.00001)(MD=3.59,95% CI [1.51,5.66],P=0.0007),一氧化碳弥散量(MD=2.54,95% CI [1.83,3.25],P<0.00001);提高生活质量,降低圣乔治评分:呼吸困难(MD=-12.70,95% CI [-21.07,-4.32],P=0.003),活动能力(MD=-8.38,95% CI [-13.66,-3.10],P=0.002),疾病影响(MD=-13.87,95% CI [-22.53,-5.22],P=0.002);并可降低患者中医症状积分:喘息(MD=-0.66,95% CI [-0.84,-0.49],P<0.00001),咳嗽(MD=-0.71,95% CI [-1.04,-0.37],P<0.0001);有效提高动脉血氧分压(MD=5.92,95% CI [4.61,7.22],P<0.00001);且不增加不良事件发生率(OR=0.55,95% CI [0.27,1.14],P=0.11)。结论 益气活血法联合西药治疗IPF可提高临床治疗有效率,改善患者生活质量,且不增加临床不良事件(便秘、嗜睡、口干、恶心呕吐、皮肤瘙痒、腹泻等)发生率。但本研究纳入文献质量参差不齐,仍需更多大样本、高质量、多中心的RCT试验验证结论。 相似文献
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多发性抽动症的发病率逐年升高,严重影响儿童生长发育及心理健康。中医治疗多发性抽动症(脾虚痰湿型)取得显著效果,但作用机制仍不明确。近年来,诸多研究表明“脾虚生痰湿”和免疫系统之间存在密切关系,还揭示了免疫机制在抽动症发病中起重要作用。本文通过概述多发性抽动症(脾虚痰湿型)的病机与免疫之间的关系,发现多发性抽动症(脾虚痰湿型)患者免疫状态与大脑皮质-基底节-丘脑-皮层回路异常密切相关,细胞免疫损伤参与了多发性抽动症的发生和发展。并分析了健脾化痰祛湿中药治疗多发性抽动症的潜在机制,为从“脾虚生痰湿”论治多发性抽动症提供相关科学依据。 相似文献
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We examine the negative child health impacts of soil zinc (Zn) deficiency in Nepal. Soil Zn deficiency limits both crop yields and the Zn concentration in food crops, leading many to speculate that it underlies human Zn deficiency and child stunting, globally and particularly in South Asia. We find strong evidence that soil Zn deficiency does have a causal impact on child stunting in Nepal’s Tarai region, the breadbasket of the country. Using causal bounds, we find that a 1 part per million increase in plant-available soil Zn – achievable with application of Zn-enriched fertilizer – decreases child stunting by between 1 and 7.5 percentage points. Multiple statistical sensitivity tests indicate that this relationship is unlikely to be manufactured by omitted, relevant variables. 相似文献
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Comprehensive evidence regarding the treatment of non-anaemic iron deficiency in patients undergoing valvular heart surgery is lacking. This study aimed to investigate the association between non-anaemic iron deficiency and postoperative outcomes in these patients. We retrospectively analysed 321 patients of which 180 (56%) had iron deficiency (defined as serum ferritin < 100 ng.ml-1 or < 300 ng.ml-1 with transferrin saturation < 20%). While the iron-deficient group had lower pre-operative haemoglobin levels than the non-iron deficient group (median (IQR [range]) 134 (127–141 [120–172]) g.l-1, 143 (133–150 [120–179]) g.l-1, p = 0.001), there was no between-group difference in allogeneic red blood cell transfusion. Median (IQR [range]) days alive and out of hospital at postoperative day 90 was 1 day shorter in the iron-deficient group (80 (77–82 [9–85]) days vs. 81 (79–83 [0–85]) days, p = 0.026). In multivariable analysis, only cardiopulmonary bypass duration (p = 0.032) and intra-operative allogeneic red blood cell transfusion (p = 0.011) were significantly associated with reduced days alive and out of hospital at postoperative day 90. Iron deficiency did not exert any adverse influence on secondary outcomes except length of hospital stay. Our findings indicate that non-anaemic iron deficiency alone is not associated with adverse effects in patients undergoing valvular heart surgery when it does not translate into an increased risk of allogeneic transfusion. 相似文献